Broad Neutralization of SARS-related Viruses by Human Monoclonal Antibodies
Broadly protective vaccines againt known and pre-emergent human coronaviruses (HCoVs) are urgently needed. To gain a deeper understanding of cross-neutralizing antibody responses, we mined the memory B cell repertoire of convalescent SARS donor and identified 200 SARS-CoV-2 binding antibodies that target miltiple conserved sites on the spike (S) protein. A large proportion of the non-neutralizing antibodies display high levels of somatic hypermutation and cross-react with circulating HCoVs, suggesting recall of pre-existing memory B cells (MBCs) elicited by prior HCoV infections. Several antibodies potently cross-neutralize SARS-CoV, SARS-CoV-2, and the bat SARS-like virus WIV1 by blocking receptor attachment and inducing S1 shedding. These antibodies represent promosing candidates for therapeutic intervention and reveal a terget for the rational design of pan-sarbecovirus vaccines.Download link journal: Click here
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