The Influence Of Supplementation of Anthocyanins on Obesity-Associated Comorbities: A Concise Review (Research Journal)
Abstract: Antocyanins are water-soluble plant pigments, and based on their chemical structure (nature, position, and the number of sugar moieties attached; and the number of hydroxyl groups; acylation of sugars with acids) about 365 different anthocyanins have been identified and reported from plants. Cyanidin, peonidin, pelargonidin,
petunidin, and malvidin are the commonly found anthocyanidins (aglycon forms of
anthocyanins) in edible plants out of almost 25 anthocyanidins that are identified
(based on the position of methoxyl and hydroxyl groups in the
rings) in nature. Anthocyanins are known for numerous health benefits including anti-diabetes, anti-obesity,
anti-inflammatory bowel disease, anti-cancer, etc. Obesity can be defined as
excessive or abnormal adipose tissue and body mass, which increases the risk of
developing chronic diseases such as diabetes, cardiovascular diseases, cancers,
etc. The manuscript summarizes the recent updates in the effects of anthocyanins supplementation on the health status of obese
subjects, and briefly the results of in vitro and in vivo
studies. Several studies confirmed that the consumption of anthocyanins-rich food
improved obesity-associated dysbiosis in gut microbiota and inflammation in adipose tissue. Anthocyanin consumption prevents obesity in healthy subjects, and aids in maintaining
or reducing the body weight of obese subjects, also improving the metabolism
and energy balance. Though preclinical studies proved the beneficial effects of anthocyanins such as the fact that daily intake of
anthocyanin rich fruits and vegetables might aid weight maintenance in every
healthy individual, Juçara pulp might
control the inflammatory status of obesity,
Queen garnet plum juice reduced the blood
pressure and risk
factors associated with metabolic disorders, and highbush organic blueberries improved the
metabolism of obese individuals, we don’t have an established treatment
procedure to prevent or manage
the over-weight condition and its comorbidities. Thus, further studies on the optimum dose, duration,
and mode of supplementation of anthocyanins are required to develop an
anthocyanins-based clinical procedure.
Keywords: anthocyanins; obesity; cyanidin-3-O-β-D-glucoside; body weight; chronic diseases.
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